Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion
نویسندگان
چکیده
منابع مشابه
Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion.
Membranoproliferative glomerulonephritis (MPGN) denotes a general pattern of glomerular injury that is easily recognized by light microscopy. With additional studies, MPGN subgrouping is possible. For example, electron microscopy resolves differences in electron-dense deposition that are classically referred to as MPGN type I (MPGN I), MPGN II, and MPGN III, while immunofluorescence typically d...
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Membranoproliferative glomerulonephritis (MPGN) is a histological pattern of injury resulting from predominantly subendothelial and mesangial deposition of immunoglobulins or complement factors with subsequent inflammation and proliferation particularly of the glomerular basement membrane. Recent classification of MPGN is based on pathogenesis dividing MPGN into immunoglobulin-associated MPGN a...
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C3 glomerulopathy (C3G) defines a group of very rare renal diseases in which dysregulation of the alternative and terminal complement pathways plays a pivotal pathogenic role. Dysregulation is driven by genetic and/or acquired defects, with interindividual variability giving rise to two broad subtypes of C3G-dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). Patient evaluation should...
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Membranoproliferative glomerulonephritis (MPGN) refers to glomerular pathology in which there is thickening of the capillary wall together with mesangial expansion. In this article we firstly review the pathological features of MPGN and discuss how advances in our understanding of the association between abnormalities in the regulation of complement and MPGN have revealed limitations in the his...
متن کاملMembranoproliferative glomerulonephritis.
Glomerulonephritis (GN) encompasses a wide variety of primary and secondary diseases that cause injury to the functioning unit of the kidney, the glomerulus. The many classifications of GN sometimes lead to confusion. This case study describes an individual with membranoproliferative GN and includes discussion of classification, treatment, and prognosis of this disease.
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ژورنال
عنوان ژورنال: Kidney International
سال: 2012
ISSN: 0085-2538
DOI: 10.1038/ki.2011.399